Search results for "Radionuclide Generators"

showing 3 items of 3 documents

Scandium-44: Benefits of a Long-Lived PET Radionuclide Available from the 44Ti/44Sc Generator System

2011

(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.

Materials scienceTransplantation HeterologousMice Nudechemistry.chemical_elementHeterocyclic Compounds 1-RingMicePositronDrug StabilityNickelNuclear ReactorsmedicineAnimalsHumansRadiology Nuclear Medicine and imagingCation Exchange ResinsScandiumChelating AgentsMice nudeRadioisotopesTitaniumPharmacologyRadionuclidemedicine.diagnostic_testRadionuclide GeneratorsLiver NeoplasmsNeoplasms ExperimentalTransplantationchemistryPositron emission tomographyPositron-Emission TomographyPuromycinAdsorptionRadiopharmaceuticalsRadionuclide GeneratorMolecular imagingScandiumHalf-LifeNuclear chemistryCurrent Radiopharmaceuticals
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Past, present and future of 68Ge/68Ga generators.

2013

(68)Ga represents one of the very early radionuclides applied to positron emission tomography (PET) imaging at a time when even the wording PET itself was not established. Today it faces a renaissance in terms of new (68)Ge/(68)Ga radionuclide generators, sophisticated (68)Ga radiopharmaceuticals, and state-of-the-art clincial diagnoses via positron emission tomography/computed tomography (PET/CT). Thanks to the pioneering achievement of radiochemists in Obninsk, Russia, a new type of (68)Ge/(68)Ga generators became commercially available in the first years of the 21st century. Generator eluates based on hydrochloric acid provided "cationic" (68)Ga instead of "inert" (68)Ga-complexes, openi…

Multimodal imagingmedicine.medical_specialtyRadiationmedicine.diagnostic_testRadionuclide GeneratorsThe RenaissanceComputed tomographyGallium RadioisotopesEngineering physicsMultimodal ImagingX ray computedPositron emission tomographyPositron-Emission TomographymedicineMedical physicsRadionuclide GeneratorRadiopharmaceuticalsTomography X-Ray ComputedApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
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Maturation of a Key Resource – The Germanium-68/Gallium-68 Generator: Development and New Insights

2011

(68)Ge/(68)Ga radionuclide generators have been investigated for almost fifty years, since the cyclotron-independent availability of positron emitting (68)Ga via the (68)Ge/(68)Ga system had always attracted researches working in basic nuclear chemistry as well as radiopharmaceutical chemistry. However, it took decades and generations of research (and researchers) to finally reach a level of (68)Ge/(68)Ga radionuclide generator designs adequate to the modern requirements of radiometal labelling chemistry. Nevertheless, most of the existing commercial generator systems address aspects of (68)Ge breakthrough and safe synthesis of (68)Ga radiopharmaceuticals by adopting eluate post-processing …

chemistry.chemical_elementGallium RadioisotopesGermaniumNanotechnologyChemical FractionationRadiology Nuclear Medicine and imagingCation Exchange ResinsProcess engineeringAnion Exchange ResinsEdetic AcidChelating AgentsRadioisotopesPharmacologyGenerator (computer programming)Gallium-68 generatorGermaniumbusiness.industryRadionuclide GeneratorsSolid Phase ExtractionChemical fractionationRadioactivitychemistryPositron-Emission TomographyRadiopharmaceuticalsRadionuclide GeneratorbusinessCurrent Radiopharmaceuticals
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